DESCRIPTION: Chat or rant, adult content, spam, insulting other members, show more. Harm to minors, violence or threats, harassment or privacy invasion, impersonation or misrepresentation, fraud or phishing, show more.Rett Butler: Favourite video by far,I died from laughter.Danish guys are cute.
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Honhoa Ong: You Know You are Dating a VENEZUELAN Man When.he is a FEMININE.
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Shelton Ross: Last Mexican Woman i dated brought her baby son on the 1st date and didnt bring diapers. All she could talk about was when we might get married. I never called her again. But she called me. Ugh. PS I have lots of experience w Latinas since i live in SoCal. Not much else to choose from here.
Again Maybe: I had an idea for another style of video you could do. It'd be something along the lines of 'Men/Women love (insert nation here women/men: 10 reasons why. You could get answers from online polls, and then have your hilarious cast re-enact them.
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Part of the work covered by Doble helice yahoo dating Nobel citation, that on the structure and replication of DNA, has been described by Wilkins in his Nobel Lecture this year. The ideas put forward by Watson and myself on the replication of DNA have also been mentioned by Kornberg in his Nobel Lecture incovering his brilliant researches on the enzymatic synthesis of DNA in the test tube. I shall discuss here the present state of a related problem in Doble helice yahoo dating transfer in material — that of the genetic code — which has long interested me, and on which my colleagues and I, among many others, have recently been doing some experimental work.
It now seems certain that the amino acid sequence of any protein is determined by the sequence of bases in some region of a particular nucleic acid molecule. Twenty different kinds of amino acid are commonly found in protein, and four main kinds of base occur in nucleic acid.
The genetic code describes the way Doble helice yahoo dating which a sequence of twenty or more things is determined by a sequence of four things of a different type. It is hardly necessary to stress the biological importance of the problem. It seems likely that most if not all the genetic information in any organism Doble helice yahoo dating carried nucleic acid — usually by DNA, although certain small viruses use RNA as their genetic material.
It is probable that much of this information is used to determine the amino acid sequence of the proteins of that organism. Whether the genetic information has any other major function we do not yet know. This idea is expressed by the classic slogan of Beadle: It is one of the more striking generalizations of biochemistry — which surprisingly hardly ever mentioned in the biochemical textbooks — that the twenty amino acids and the four bases, are, with minor reservations, the same throughout Nature.
In this lecture I shall not deal with the intimate technical details of the problem, if only for the reason that I have recently written such a review 1 which will appear shortly.
Nor shall I deal with the biochemical details of messenger RNA and protein synthesis, as Watson has already spoken about these. Rather I shall ask certain general questions about the genetic code and ask how far we can now answer them. Let us assume that the genetic code is a simple one and ask how many bases code for one amino acid? However, triplets of bases would give us 64 possibilities.
This brings us to our first question. In other words, as we read along the genetic message do we find a base which is a member of two or more codons?
It now seems fairly certain that codons do not overlap. In all probability, therefore, codons do not overlap. This leads us to the next problem. How is the base sequence, divided into codons? There is nothing in the backbone of the nucleic acid, which is perfectly regular, to show us how to group the bases into codons.
Doble helice yahoo dating, for example, all the codons are triplets, then in addition to the correct reading of the message, there are two incorrect readings which we shall obtain if we do not start the grouping into sets of three at the right place. My colleagues and I 3 have recently obtained experimental evidence that each section of the genetic message is indeed read from a fixed point, probably from one end.
This fits in very well with the experimental evidence, most clearly shown in the work of Dintzis 4 that the amino acids are assembled into the polypeptide chain in a linear order, starting at the amino end of the chain. This leads us to the next general question: How many bases are there in any one
Doble helice yahoo dating The same experiments to which I have just 3 strongly suggest that all or almost all codons consist of a triplet of bases, though a small multiple of three, such as six or nine, is not completely ruled out by our data.
We were led to this conclusion by the study of mutations in the A and B cistrons of the r II locus of bacteriophage T4. Doble helice yahoo dating mutations are believed to be due to the addition or subtraction of one or more bases from the genetic message. They are typically produced by acridines, and cannot be reversed by mutagens which merely change one base into another.
Moreover these mutations almost always render the gene completely inactive, rather than partly so. The crucial experiment is to put together, by genetic recombination, three mutants of the same type into one gene.
Detailed examination of these results show that they are exactly what we should expect if the message were read in triplets starting from one end. Such a combination is active as expected on our theory, although sets of four or five of them are not.
That is, combinations in which the gene is working at very low efficiency. These results also enable us to tie down the direction of reading of the genetic message, which in this case is from left to right, as the r II region is conventionally drawn.
We plan to write up a detailed technical account of all this work shortly. A final proof of our ideas can only be obtained by detailed studies on the alterations produced in the amino acid sequence of a protein by mutations of the type discussed here.
One further conclusion of a general nature is suggested by our results. It would appear that the Doble helice yahoo dating of nonsense triplets is rather low, since we only occasionally come across them. However this conclusion is less secure than our other deductions about the general nature of the genetic code. It has not yet been shown directly that the genetic message is co-linear with
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That is, that one end of the gene codes for the amino end of the polypeptide chain and the other for the carboxyl end, and that as one proceeds along gene one comes in turn to the codons in between in the linear order in which the amino acids are found in the polypeptide chain. This seems highly likely, especially as it has been shown that in several systems mutations affecting the same amino acid are extremely near together on the genetic map.
The experimental proof of the co-linearity of a gene and the polypeptide chain it produces Doble helice yahoo dating be confidently expected within the next year or so.
There is one further general question about the genetic code which we can ask at this Doble helice yahoo dating. Is the code universal, that is, the same in all organisms? Preliminary evidence suggests that it may well be. Doble helice yahoo dating example something very like rabbit haemoglobin can be synthesized using a cell-free system, part of which comes from rabbit reticulocytes and part from Escherichia coli 5.
This would not be very probable if the code were very different in these two organisms. However as we shall see it is now possible to test the universality of the code by more direct experiments. In a cell in which DNA is the genetic material it is not believed that DNA itself controls protein Doble helice yahoo dating directly. As Watson has described, it is believed that the base sequence of the DNA — probably of only one of its chains — is copied onto RNA, and that this special RNA then acts as the genetic messenger and directs the actual of joining up the amino acids into polypeptide chains.
The breakthrough in the coding problem has come from the discovery, made by Nirenberg and Matthaei 6that one can use synthetic RNA for this purpose. In particular they found that polyuridylic acid — an RNA in which every base is uracil — will promote the synthesis
Doble helice yahoo dating polyphenylalanine when added to a cell-free system which was Doble helice yahoo dating known to synthesize polypeptide chains. Thus one codon for phenylalanine appears to be the sequence UUU where U stands for uracil: This discovery has opened the way to a rapid although somewhat confused attack on the genetic code.
It would not be appropriate to review this work in detail here. I have discussed critically the earlier work in the review mentioned previously 1 but such is the pace of work in this field that more recent experiments have already made it out of date to some extent. However, some general conclusions can safely be drawn. For example, a polynucleotide, which I shall call poly U,Chaving about equal amounts of uracil and cytosine in presumably random order will increase the incorporation of the amino acids phenylalanine, serine, leucine, and proline, and possibly threonine.
By using polymers of different composition and assuming a triplet code one can deduce limited Doble helice yahoo dating about the composition of certain triplets. From such work it appears that, with minor reservations, each polynucleotide incorporates a characteristic set of amino acids. Moreover the four bases appear quite distinct in their effects.
A comparison between the triplets tentatively deduced by these methods with the changes in amino acid sequence produced by mutation shows a fair measure of agreement. Moreover the incorporation requires the same components needed for protein synthesis, and is inhibited by the same inhibitors.
Thus the system is most unlikely to be a complete artefact and is very probably closely related to genuine protein synthesis. As to the actual triplets so far proposed it was first thought that possibly every triplet had to include uracil, but this was neither plausible on theoretical grounds nor supported by the actual experimental evidence.
The first direct evidence that this was not so was obtained by my colleagues Bretscher and Grunberg-Manago 8who showed that a poly C,A would stimulate the incorporation of several amino acids.
Recently other worker 910 have reported further evidence of this sort for other polynucleotides not containing uracil. It now seems very likely that many of the 64 triplets, possibly most of them, may code one amino acid or another, and that in general several distinct triplets may code one amino acid.
In particular a very elegant experiment II suggests that both UUC and UUG code leucine the brackets imply that the order within the triplets is not yet known. This general idea is supported by several indirect lines of evidence which cannot be detailed here. Unfortunately it makes the unambiguous determination of triplets by these methods much more difficult than would be the case if there were only one triplet for each amino acid.
A start has been made to construct polynucleotides whose exact sequence is known at one end, but the results obtained so far are suggestive rather than conclusive It seems virtually certain that a single chain of RNA can act as messenger RNA, since poly U is a single without secondary structure. If poly A is added to poly U, to form a double or triple helix, the combination is inactive.
Moreover there is preliminary evidence 9 which suggests that secondary structure within a polynucleotide inhibits the power to stimulate protein synthesis. It has yet to be shown by direct biochemical methods, as opposed to the indirect genetic evidence mentioned earlier, that the code is indeed a triplet code. Attempts have been made from a study of the changes produced by mutation to obtain the relative order of the bases within various triplets, but my own view is that these are premature until there is more extensive and more reliable data on the composition of the triplets.
Evidence presented by several groups 8 Doble helice yahoo dating, 9, 11 suggest that poly U stimulates both the incorporation of phenylalanine and also a lesser amount of leucine. The meaning of this observation is unclear, but it raises the unfortunate possibility of ambiguous triplets; that is, triplets which may code more than one amino acid. However one would certainly expect such triplets to be in a minority. It Doble helice yahoo dating seem likely, then, that most of the sixty-four possible triplets will be grouped into twenty groups.
The balance of evidence both from the cell-free system and from the study of mutation, suggests that this does Doble helice yahoo dating occur at random, and that triplets coding the same amino acid may well be rather similar. This raises the main theoretical problem now outstanding. Can this grouping be deduced from theoretical postulates? Unfortunately, it is not difficult to see how it might have arisen at an extremely early stage in evolution by random mutations, so that the particular code we have may perhaps be the result of a series of historical accidents.
This point is of more than abstract interest. If the code does indeed have some logical foundation then it is legitimate to consider all the evidence, both good and bad, in any attempt to deduce it.
The same is not true if the codons have no simple logical connection. In that case, it makes little sense to guess a codon. The important thing is to provide enough evidence to prove each codon independently.
It is yet clear what evidence can safely be accepted as establishing a codon. What is clear is that most of the experimental evidence so far presented falls short of proof in almost all cases. In spite of the uncertainty of much of the experimental data there are certain codes which have been suggested in the past which we can now reject with some degree of confidence.
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Region of the make covered by the Nobel citation, that on the shape and replication of DNA, has dead described by Wilkins in his Nobel Lecture this year. The ideas trouble forward by Watson and myself on the replication of DNA have too been mentioned beside Kornberg in his Nobel Lecture in , covering his brilliant researches on the enzymatic composite of DNA in the test tube.
I shall consult on here the accounted for right state of a related problem in information transfer in living material — that of the genetic code — which has prolonged interested me, and on which my colleagues and I, among many others, have recently old-time doing some conjectural work. It fashionable seems certain that the amino acid sequence of any protein is identified by the line of bases in some region of a particular nucleic acid molecule.
Twenty different kinds of amino acid are commonly found in protein, and four main kinds of base occur in nucleic acid. The genetic code describes the way in which a arrangement of twenty or more things is determined by a sequence of four things of a different type.
It is hardly unavoidable to stress the biological importance of the problem. It seems likely that most if not all the genetic information in any organism is carried by nucleic acid — usually close DNA, although assertive small viruses take advantage of RNA as their genetic material.
It is probable that much of that information is employed to determine the amino acid arrangement of the proteins of that being. Whether the genetic information has any other major duty we do not yet know.
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